Yeah, I think it’s interesting… handicaps favor the better player in head to head matchups, since they will be more likely to play close to their handicap, but with a large enough field of high handicaps, lower handicaps are at a disadvantage simply due to variance.
It’s definitely worth knowing what advantages you have when playing for money… I love skins games as a 6 handicap, because I’m long enough to reach most par fives and the hardest par fours are usually the longest, so are good places for me to outperform my handicap.